Minocycline impurity
Time:2024-05-08
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Minocycline is a broad-spectrum antibiotic of the tetracycline group, with high efficiency and long-lasting effect, and has a strong antibacterial effect among tetracycline
The main toxicities of minocycline have been found to be respiratory sensitization, chromosomal mutation potential, reproductive toxicity, and mutagenicity.Mutagenicity.
The main toxicities of minocycline have been found to be respiratory sensitization, chromosomal mutation potential, reproductive toxicity, and mutagenicity.Mutagenicity.
During the synthesis of some minocyclines, because of the presence of differential minocycline (minocycline EP impurity A) in the raw material itself, and the increase of its content by light destruction and high temperature destruction, the impurity poorly oriented minocycline is both a synthesis by-product and can be produced by degradation.Minocycline EP impurity F is produced by degradation, and the rest of the impurities are by-products of the raw material synthesis process.
At present, minocycline hydrochloride formulations are mainly in the shape of powder, capsules and micro-pills, the main factor affecting the dissolution rate of powder capsules is the disintegration rate of the capsule shell, while the micro-pill capsules are mainly in the shape of powder, capsules and micro-pills.CDEFFV
The main factor affecting the dissolution rate of powder capsules is the disintegration rate of the capsule shell, while the dissolution rate of micropill capsules is affected by the disintegration rate of the capsule shell, the solubility of minocycline hydrochloride in different pH media, as well as the characteristics of the micropill dosage form.
The dissolution rate of microcapsules is influenced by the disintegration rate of the capsule shell, the solubility of minocycline hydrochloride in different pH media, and the dosage form characteristics of microcapsules. In addition, minocycline hydrochloride is hygroscopic, and the water permeability and air permeability of the packaging material may lead to changes in product quality.
In addition, Minocycline Hydrochloride has moisture attracting properties, and the quality characteristics of the packaging material such as water permeability and air permeability may lead to product quality changes.
SZEB supplies Minocycline impurity control/standard products, the following is a partial catalog of Minocycline impurity control/standard products:
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